Adult-Gerontology CNS Practice Exam 2026 – Complete Prep Guide

As people age, research indicates that the density and functionality of serotonin receptors can decrease. This reduction has been linked to aging and can have implications for mood regulation, cognitive function, and various neuropsychiatric disorders. The decline in serotonin receptor availability may contribute to the increased prevalence of depression and anxiety in older adults, as serotonin plays a crucial role in mood stabilization and emotional wellbeing.

This decline is not uniform across all serotonin receptor subtypes, but there is a general trend towards decreased receptor sensitivity and availability with aging. Factors such as changes in receptor gene expression, neurobiology, and the potential for neurodegeneration could contribute to this phenomenon. Understanding these changes is critical for addressing mental health and cognitive challenges in the geriatric population.